It is stated that MP4247 can deliver 100W, “at certain input voltages”.
The datasheet does not give more information about these “certain voltages”, but i have an idea that it has to do with the effeciency and power dissipation, at different input voltages.
Ha! good luck with that. One limit could be imposed by the current limit of the internal low side FETs
So the question would be what is the minimum current limit of say the low side FET that is operated in the boost mode (Switch C). No minimum is specified, the datasheet is a useless document for answering this question. The limit is typically 15A So if you are content to go to production with a design that typically works, but hey no guarantees!. Then allowing for 5% efficiency loss and designing for 40% pk-pk current ripple you can draw about 11A from the input. So 100W from 12V in will probably be OK.
Internet rando, but that is 5A on the input side and 7 or so on the output side. I would say no problem. If you can get a demo or eval board that would be money well spent.