The MP2153 looks like a good candidate for my 3.3V/2.5A rail and my input range is 4V-5V. Can this device support this
Yes, the MP2153 switches at 1.1MHz. At Vin = 4V, the buck power stage minimum off-time is (1-3.3V/4V)/1.1MHz or 159ns. This is above the MP2153 minimum off-time spec of 100ns.